Publications
Find coverage of the latest original articles on scleroderma, focusing on those with data on therapeutic interventions and those that have clinical impact.
Sponsored by Boehringer Ingelheim.
June 2025
Faecal microbiota transplantation in patients with systemic sclerosis and lower gastrointestinal tract symptoms in Norway (ReSScue): a phase 2, randomised, double-blind, placebo-controlled trial
Lancet Rheumatol 2025;7:e323–32 doi: org/10.1016/S2665-9913(24)00334-5
Fretheim et al. showed that the faecal microbiota transplantation with ACHIM was well-tolerated in participants with systemic sclerosis but did not result in an improvement in lower GIT symptoms. Fretheim et al. compared the effects of repeated upper intestinal infusions of ACHIM with placebo in patients with systemic sclerosis and moderate-to-severe lower GIT symptoms. The ReSScue trial provides valuable insights that can inform future GIT studies in patients with systemic sclerosis.